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          Institute: MPI für biologische Kybernetik     Collection: Biologische Kybernetik     Display Documents



ID: 595861.0, MPI für biologische Kybernetik / Biologische Kybernetik
Structure-related variable responses of calcium sensitive MRI probes
Authors:Mamdedov, I; Logothetis, NK; Angelovski, G
Date of Publication (YYYY-MM-DD):2011-07-01
Title of Journal:Organic & Biomolecular Chemistry
Volume:9
Issue / Number:16
Start Page:5816
End Page:5824
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:A new series of Gd3+ complexes based on DO3A (GdL1–GdL4) was synthesized and investigated. They possess side chains with different structures which determine their varying binding properties and response towards endogenous metal ions, measured by changes in the longitudinal relaxivity (r1). GdL4 exhibits the highest selectivity toward Ca2+ in comparison to the other complexes, with up to a 63% increase of the r1. GdL2 and GdL3 also respond to different Ca2+ concentration ranges, however with a lower selectivity since the r1 changes are also observed in the presence of other cations such as Mg2+, Zn2+ or Cu2+. Assessment of the hydration number (q) via luminescence lifetime measurements confirmed that the change in q is responsible for the r1 response for all the complexes.
External Publication Status:published
Document Type:Article
Communicated by:Holger Fischer
Affiliations:MPI für biologische Kybernetik/Neurophysiology (Dept. Logothetis)
Identifiers:LOCALID:MamdedovLA2011
URL:http://www.kyb.tuebingen.mpg.de/
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