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          Institute: MPI für biologische Kybernetik     Collection: Biologische Kybernetik     Display Documents



ID: 595868.0, MPI für biologische Kybernetik / Biologische Kybernetik
Cation-Responsive MRI Contrast Agents Based on Gadolinium(III)
Authors:Angelovski, G; Mamedov, I
Date of Publication (YYYY-MM-DD):2011-05-01
Title of Journal:Current Inorganic Chemistry
Volume:1
Issue / Number:1
Start Page:76
End Page:90
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:Magnetic resonance imaging (MRI) offers the ability to visualize a number of biological processes at the molecular and cellular level. The quest for MRI methods that enable the monitoring of these processes with improved specificity and spatiotemporal resolution has induced a considerable amount of research into the chemistry of contrast agents. A novel class of agents has been developed that is able to report a change in its magnetic properties as a function of a specific parameter in the surrounding microenvironment. The vast majority consist of paramagnetic Gd3+ complexes that enhance the contrast in the MR image upon a change in the local concentration of a biologically relevant ion, such as H+, Ca2+, Zn2+, or Cu2+. This review summarizes their coordination chemistry and further aspects of these responsive paramagnetic complexes and discusses the most recent examples that are described in the literature.
External Publication Status:published
Document Type:Article
Communicated by:Holger Fischer
Affiliations:MPI für biologische Kybernetik/Neurophysiology (Dept. Logothetis)
Identifiers:LOCALID:AngelovskiM2011
URL:http://www.kyb.tuebingen.mpg.de/
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