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          Institute: MPI für Intelligente Systeme (ehemals Max-Planck-Institut für Metallforschung)     Collection: Abt. Schölkopf (Empirical Inference)     Display Documents



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ID: 596132.0, MPI für Intelligente Systeme (ehemals Max-Planck-Institut für Metallforschung) / Abt. Schölkopf (Empirical Inference)
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-Å resolution
Authors:Armache, J.-P.; Jarasch, A.; Anger, A. M.; Villa, E.; Becker, T.; Bhushan, S.; Jossinet, F.; Habeck, M.; Dindar, G.; Franckenberg, S.; Marquez, V.; Mielke, T.; Thomm, M.; Berninghausen, O.; Beatrix, B.; Söding, J.; Westhof, E.; Wilson, D. N.; Beckmann, R.
Date of Publication (YYYY-MM-DD):2010
Title of Journal:Proceedings of the National Academy of Sciences of the United States of America
Volume:107
Issue / Number:46
Start Page:19748
End Page:19753
Review Status:not specified
Audience:Not Specified
Intended Educational Use:No
Abstract / Description:Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reconstruction, we have determined the structure of a translating plant (Triticum aestivum) 80S ribosome at 5.5-Å resolution. This map, together with a 6.1-Å map of a Saccharomyces cerevisiae 80S ribosome, has enabled us to model ∼98% of the rRNA. Accurate assignment of the rRNA expansion segments (ES) and variable regions has revealed unique ES–ES and r-protein–ES interactions, providing insight into the structure and evolution of the eukaryotic ribosome.
External Publication Status:published
Document Type:Article
Communicated by:Heide Klooz
Affiliations:MPI für Intelligente Systeme/Abt. Schölkopf
Identifiers:URL:http://www.kyb.tuebingen.mpg.de/
LOCALID:ArmacheJAVBBJHDFMMTBBSWWB2011
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