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          Institute: MPI für medizinische Forschung     Collection: jahrbuch_2011_archival     Display Documents



ID: 597761.0, MPI für medizinische Forschung / jahrbuch_2011_archival
Large−scale automated histology in the pursuit of connectomes
Translation of Title:Large−scale automated histology in the pursuit of connectomes
Authors:Kleinfeld, David; Bharioke, Arjun; Blinder, Pablo; Bock, Davi D.; Briggman, Kevin L.; Chklovskii, Dmitri B.; Denk, Winfried; Helmstaedter, Moritz; Kaufhold, John P.; Lee, Wei−Chung Allen; Meyer, Hanno S.; Micheva, Kristina D.; Oberlaender, Marcel; Prohaska, Steffen; Reid, R. Clay; Smith, Stephen J.; Takemura, Shinya; Tsai, Philbert S.; Sakmann, Bert
Language:English
Date of Publication (YYYY-MM-DD):2011-11-09
Title of Journal:Journal of Neuroscience
Journal Abbrev.:J. Neurosci.
Volume:31
Issue / Number:45
Start Page:16125
End Page:16138
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:How does the brain compute? Answering this question necessitates neuronal connectomes, annotated graphs of all synaptic connections within defined brain areas. Further, understanding the energetics of the brain's computations requires vascular graphs. The assembly of a connectome requires sensitive hardware tools to measure neuronal and neurovascular features in all three dimensions, as well as software and machine learning for data analysis and visualization. We present the state of the art on the reconstruction of circuits and vasculature that link brain anatomy and function. Analysis at the scale of tens of nanometers yields connections between identified neurons, while analysis at the micrometer scale yields probabilistic rules of connection between neurons and exact vascular connectivity
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Biomedizinische Optik
MPI für medizinische Forschung/Abteilung Zellphysiologie/Kortikale Schaltkreise
MPI für medizinische Forschung/Abteilung Zellphysiologie/Quantitative Neurobiologie
MPI für medizinische Forschung/Abteilung Biomedizinische Optik/Gruppe Moritz Helmstaedter
Identifiers:LOCALID:7727
URI:http%3A%2F%2Fwww.jneurosci.org%2Fcontent%2F31%2F45...
URI:http%3A%2F%2Fwww.jneurosci.org%2Fcontent%2F31%2F45...
URI:http%3A%2F%2Fwww.jneurosci.org%2Fcontent%2F31%2F45...
DOI:10.1523%2FJNEUROSCI.4077-11.2011
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