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          Institute: MPI für medizinische Forschung     Collection: jahrbuch_2011_archival     Display Documents



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ID: 597762.0, MPI für medizinische Forschung / jahrbuch_2011_archival
Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A
Translation of Title:Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A
Authors:Meyer, Hanno S.; Schwarz, Daniel; Wimmer, Verena C.; Schmitt, Arno C.; Kerr, Jason N. D.; Sakmann, Bert; Helmstaedter, Moritz
Language:English
Date of Publication (YYYY-MM-DD):2011-10-04
Title of Journal:Proceedings of the National Academy of Sciences of the USA (JSTOR)
Journal Abbrev.:Proc. Natl. Acad. Sci. U. S. A.
Volume:108
Issue / Number:40
Start Page:16807
End Page:16812
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Although physiological data on microcircuits involving a few inhibitory neurons in the mammalian cerebral cortex are available, data on the quantitative relation between inhibition and excitation in cortical circuits involving thousands of neurons are largely missing. Because the distribution of neurons is very inhomogeneous in the cerebral cortex, it is critical to map all neurons in a given volume rather than to rely on sparse sampling methods. Here, we report the comprehensive mapping of interneurons (INs) in cortical columns of rat somatosensory cortex, immunolabeled for neuron−specific nuclear protein and glutamate decarboxylase. We found that a column contains ˜2,200 INs (11.5% of ˜19,000 neurons), almost a factor of 2 less than previously estimated. The density of GABAergic neurons was inhomogeneous between layers, with peaks in the upper third of L2/3 and in L5A. IN density therefore defines a distinct layer 2 in the sensory neocortex. In addition, immunohistochemical markers of IN subtypes were layer−specific. The
Free Keywords:barrel cortex | parvalbumin | somatostatin | calretinin
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Biomedizinische Optik
MPI für medizinische Forschung/Abteilung Zellphysiologie/Kortikale Schaltkreise
MPI für medizinische Forschung/Abteilung Zellphysiologie/Synaptische Transmission - molekulare Mechanismen und strukturelle Organisation
MPI für medizinische Forschung/Abteilung Biomedizinische Optik/Gruppe Moritz Helmstaedter
MPI für medizinische Forschung/Max-Planck-Forschungsgruppe Neurophysiologie des Verhaltens (Andreas T. Schaefer)
Identifiers:LOCALID:7726
URI:http%3A%2F%2Fwww.pnas.org%2Fcontent%2F108%2F40%2F1...
URI:http%3A%2F%2Fwww.pnas.org%2Fcontent%2F108%2F40%2F1...
URI:http%3A%2F%2Fwww.pnas.org%2Fcontent%2Fearly%2F2011...
DOI:10.1073%2Fpnas.1113648108
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