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          Institute: MPI für medizinische Forschung     Collection: jahrbuch_2011_archival     Display Documents



ID: 597767.0, MPI für medizinische Forschung / jahrbuch_2011_archival
Requirement of the RNA−editing enzyme ADAR2 for normal physiology in mice
Translation of Title:Requirement of the RNA−editing enzyme ADAR2 for normal physiology in mice
Authors:Horsch, M.; Seeburg, Peter H.; Adler, T.; Aguilar−Pimentel, J. A.; Becker, L.; Calzada−Wack, J.; Garrett, L.; Götz, A.; Hans, W.; Higuchi, Miyoko; Hölter, S. M.; Naton, B.; Prehn, C.; Puk, O.; Rácz, I.; Rathkolb, B.; Rozman, J.; Schrewe, A.; Adamski, J.; Busch, D. H.; Esposito, I.; Graw, J.; Ivandic, B.; Klingenspor, M.; Klopstock, T.; Mempel, M.; Ollert, M.; Schulz, H.; Wolf, Eva; Wurst, W.; Zimmer, A.; Gailus−Durner, V.; Fuchs, H.; Hrabe de Angelis, M.; Beckers, J.
Language:English
Date of Publication (YYYY-MM-DD):2011-05-27
Title of Journal:Journal of Biological Chemistry
Journal Abbrev.:J. Biol. Chem.
Volume:286
Issue / Number:21
Start Page:18614
End Page:18622
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:ADAR2, an RNA editing enzyme that converts specific adenosines to inosines in certain pre−mRNAs, often leading to amino acid substitutions in the encoded proteins, is mainly expressed in brain. Of all ADAR2−mediated edits, a single one in the pre−mRNA of the AMPA receptor subunit GluA2 is essential for survival. Hence, early postnatal death of mice lacking ADAR2 is averted when the critical edit is engineered into both GluA2 encoding Gria2 alleles. Adar2(−/−)/Gria2(R/R) mice display normal appearance and life span, but the general phenotypic effects of global lack of ADAR2 have remained unexplored. Here we have employed the Adar2(−/−)/Gria2(R/R) mouse line, and Gria2(R/R) mice as controls, to study the phenotypic consequences of loss of all ADAR2−mediated edits except the critical one in GluA2. Our extended phenotypic analysis covering ~320 parameters identified significant changes related to absence of ADAR2 in behavior, hearing ability, allergy parameters and transcript profiles of brain
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Identifiers:LOCALID:7718
URI:http%3A%2F%2Fwww.jbc.org%2Fcontent%2F286%2F21%2F18...
URI:http%3A%2F%2Fwww.jbc.org%2Fcontent%2F286%2F21%2F18...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21467...
DOI:10.1074%2Fjbc.M110.200881
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