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          Institute: MPI für medizinische Forschung     Collection: jahrbuch_2011_archival     Display Documents

ID: 597768.0, MPI für medizinische Forschung / jahrbuch_2011_archival
Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice
Translation of Title:Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice
Authors:Grinevich, V.; Jezova, D.; Gambaryan, S.; Illarionova, A.; Kolleker, A.; Seeburg, Peter H.; Schwarz, Martin K.
Date of Publication (YYYY-MM-DD):2011-07-19
Title of Journal:Hormone and Metabolic Research = Hormon− und Stoffwechselforschung = Hormones et Métabolisme
Journal Abbrev.:Hormone and metabolic research = Hormon− und Stoff
Issue / Number:8
Start Page:551
End Page:556
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Homer 1 gene products are involved in synaptic transmission and plasticity, and hence, distinct behavioral abnormalities, including anxiety− and depression−like behaviors, have been observed in Homer 1 knockout (KO) mice. Here we report that Homer 1 KO mice additionally exhibit a pronounced endocrine phenotype, displaying a profoundly increased adrenal gland weight and increased adrenal/body weight ratio. Histological examinations of Homer 1 deficient adrenal glands revealed an increased size of the adrenal cortex, especially the sizes of the zona fasciculata and zona glomerulosa. Moreover, the plasma corticosterone and aldosterone were higher in Homer 1 KO than wild−type (WT) mice while the plasma ACTH levels were not different between the genotypes. The in vivo ACTH test revealed that corticosterone and aldosterone plasma levels were higher in saline injected Homer 1 KO mice than in WT mice (saline injected mice served as controls for the respective groups of ACTH−injected animals), but the magnitude of steroid responses to ACTH was similar in both genotypes. In contrast, an in vitro experiment performed on isolated cells of adrenal cortex clearly showed increased production of both steroids in response to ACTH in Homer 1 KO cells, which is in line with an ˜8−fold increase in the expression of ACTH receptor mRNA in the adrenal cortex of these mutants. These results, together with the detection of Homer 1 mRNA and protein in the adrenal cortex of WT mice, indicate that Homer 1 directly affects the steroidogenic function of the adrenal glands
Free Keywords:adrenal cortex − glucocorticoids − HPA−axis − aldosterone
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Martin Schwarz
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