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          Institute: MPI für medizinische Forschung     Collection: jahrbuch_2011_archival     Display Documents



ID: 597771.0, MPI für medizinische Forschung / jahrbuch_2011_archival
Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization
Translation of Title:Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization
Authors:Parkitna, Jan Rodriguez; Solecki, Wojciech; Golembiowska, Krystyna; Tokarski, Krzysztof; Kubik, Jakub; Golda, Slawomir; Novak, Martin; Parlato, Rosanna; Hess, Grzegorz; Sprengel, Rolf; Przewlocki, Ryszard
Language:English
Date of Publication (YYYY-MM-DD):2011-11-01
Title of Journal:The International Journal of Neuropsychopharmacology
Journal Abbrev.:The International Journal of Neuropsychopharmacolo
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The brain's noradrenergic system is involved in the development of behaviours induced by drugs of abuse, e.g. dependence and withdrawal, and also reward or psychomotor effects. To investigate how noradrenergic system activity is controlled in the context associated with drug−induced behaviours, we generated a Cre/loxP mouse model in which the essential glutamate NMDA receptor subunit NR1 is ablated in cells expressing dopamine β−hydroxylase (Dbh). As a result, the noradrenergic cells in NR1DbhCre mice lack the NMDA receptor−dependent component of excitatory post−synaptic currents. The mutant mice displayed no obvious behavioural alterations, had unchanged noradrenaline content and mild increase in dopamine levels in the nucleus accumbens. Interestingly, NR1DbhCre animals did not develop morphine−induced psychomotor sensitization. However, when the morphine injections were preceded by treatment with RX821002, an antagonist of α2−adrenergic receptors, the development of sensitization was restored. Conversely, pretreatment with clonidine, an agonist of α2−adrenergic receptors, blocked development of sensitization in wild−type mice. We also found that while the development of tolerance to morphine was normal in mutant mice, withdrawal symptoms were attenuated. These data reveal that NMDA receptors on noradrenergic neurons regulate development of opiate dependence and psychomotor sensitization, by controlling drug−induced noradrenaline signalling
Free Keywords:Morphine;
NMDA receptor;
noradrenaline;
reinforcement;
sensitization;
withdrawal
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7711
URI:http%3A%2F%2Fjournals.cambridge.org%2Fdownload.php...
URI:http%3A%2F%2Fjournals.cambridge.org%2Faction%2Fdis...
URI:http%3A%2F%2Fjournals.cambridge.org%2Faction%2Fdis...
DOI:DOI%3A10.1017%2FS1461145711001568
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