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          Institute: MPI für medizinische Forschung     Collection: jahrbuch_2011_archival     Display Documents



ID: 597775.0, MPI für medizinische Forschung / jahrbuch_2011_archival
Dissociations within short−term memory in GluA1 AMPA receptor subunit knockout mice
Translation of Title:Dissociations within short−term memory in GluA1 AMPA receptor subunit knockout mice
Authors:Taylor, Amy M.; Niewoehner, Burkhard; Seeburg, Peter H.; Sprengel, Rolf; Rawlins, J. Nicholas P.; Bannerman, David M.; Sanderson, David J.
Language:English
Date of Publication (YYYY-MM-DD):2011-10-10
Title of Journal:Behavioural Brain Research
Journal Abbrev.:Behavioural Brain Research
Volume:224
Issue / Number:1
Start Page:8
End Page:14
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:GluA1 AMPA receptor subunit knockout mice display a selective impairment on short−term recognition memory tasks. In this study we tested whether GluA1 is important for short−term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short−term memory traces of T−maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short−term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short−term memory traces. Memory that results in performance of short−term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning
Free Keywords:AMPA receptors; Conditional learning; Trace conditioning; Non−spatial memory; Spatial memory
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7700
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.bbr.2011.05....
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F21641...
DOI:10.1016%2Fj.bbr.2011.05.016
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