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          Institute: MPI für molekulare Physiologie     Collection: Abteilung IV - Chemische Biologie     Display Documents



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ID: 6069.0, MPI für molekulare Physiologie / Abteilung IV - Chemische Biologie
Natural product guided compound library development
Authors:Breinbauer, Rolf; Manger, Michael; Scheck, Michael; Waldmann, Herbert
Language:English
Research Context:combinatorial chemistry
Date of Publication (YYYY-MM-DD):2002-12
Title of Journal:Current Medicinal Chemistry
Journal Abbrev.:Curr. Med. Chem.
Volume:9
Issue / Number:23
Start Page:2129
End Page:2145
Sequence Number of Article:1
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Natural products are biologically validated starting points for the design of combinatorial libraries, as they have a proven record of biological relevance. This special role of natural products in medicinal chemistry and chemical biology can be interpreted in the light of new insights about the domain architecture of proteins gained by structural biology and bioinformatics. In order to fulfil the specific requirements of the individual binding pocket within a domain family it is necessary to optimise the natural product structure by chemical variation. Solid-phase chemistry is becoming an efficient tool for this optimisation process, and recent advances in this field are highlighted in this review article.
Free Keywords:combinatorial chemistry; drug discovery; lead optimisation; natural products; organic synthesis; protein domains; solid phase synthesis
External Publication Status:published
Document Type:Article
Affiliations:MPI für molekulare Physiologie/Abteilung IV - Chemische Biologie/AG Prof. Dr. Herbert Waldmann
MPI für molekulare Physiologie/Abteilung IV - Chemische Biologie/AG Dr. Rolf-Peter Breinbauer
External Affiliations:Univ Dortmund, Fachbereich 3, D-44221 Dortmund, Germany
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