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          Institute: MPI für Evolutionsbiologie     Collection: Evolutionary genetics     Display Documents



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ID: 608599.0, MPI für Evolutionsbiologie / Evolutionary genetics
Parallel selection mapping using artificially selected mice reveals body weight control loci
Authors:Chan, Yingguang Frank; Jones, Felicity C.; McConnell, Ellen; Bryk, Jarosław; Bünger, Lutz; Tautz, Diethard
Language:English
Date of Publication (YYYY-MM-DD):2012-03-22
Title of Journal:Current Biology
Volume:22
Sequence Number of Article:published online
Review Status:not specified
Audience:Not Specified
Abstract / Description:Understanding how polygenic traits evolve under selection is an unsolved problem [], because challenges exist for identifying genes underlying a complex trait and understanding how multilocus selection operates in the genome. Here we study polygenic response to selection using artificial selection experiments. Inbred strains from seven independent long-term selection experiments for extreme mouse body weight ("high" lines weigh 42-77 g versus 16-40 g in "control" lines) [] were genotyped at 527,572 SNPs to identify loci controlling body weight. We identified 67 parallel selected regions (PSRs) where high lines share variants rarely found among the controls. By comparing allele frequencies in one selection experiment [] against its unselected control, we found classical selective sweeps centered on the PSRs. We present evidence supporting two G protein-coupled receptors GPR133 and Prlhr as positional candidates controlling body weight. Artificial selection may mimic natural selection in the wild: compared to control loci, we detected reduced heterozygosity in PSRs in unusually large wild mice on islands. Many PSRs overlap loci associated with human height variation [], possibly through evolutionary conserved functional pathways. Our data suggest that parallel selection on complex traits may evoke parallel responses at many genes involved in diverse but relevant pathways. © 2012 Elsevier Ltd. All rights reserved.
External Publication Status:published
Document Type:Article
Communicated by:Brigitte Lechner
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsgenetik
MPI für Evolutionsbiologie/Max Planck Research Group Experimental Evolution
External Affiliations:Department of Developmental Biology, Stanford University, B-300 Beckman Center, 279 Campus Drive Loop, Stanford, CA 94305, USA; Animal and Veterinary Sciences Research Group, Scottish Agricultural College, Midlothian, EH25 9RG, UK
Identifiers:ISSN:0960-9822 (print) [ID-No:1]
ISSN:1879-0445 (online) [ID-No:2]
DOI:10.1016/j.cub.2012.03.011 [ID-No:3]
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