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Home Search Quick Search Advanced Fulltext Browse Collections Persons My eDoc Session History Login Name: Password: Documentation Help Support Wiki Direct access to document ID:	Institute: MPI für Dynamik komplexer technischer Systeme     Collection: Physical and Chemical Foundations of Process Engineering     Display Documents   history ID: 609988.0, MPI für Dynamik komplexer technischer Systeme / Physical and Chemical Foundations of Process Engineering Resolution of a Diasteromeric Salt of Citalopram by Multistage Crystallization Authors: Balawejder, Maciej; Kiwala, Dawid; Lorenz, Heike; Seidel-Morgenstern, Andreas; Piatkowski, Wojciech; Antos, Dorota Language: English Date of Publication (YYYY-MM-DD): 2012 Title of Journal: Crystal Growth & Design Volume: 12 Issue / Number: 5 Start Page: 2557 End Page: 2566 Review Status: Peer-review Audience: Experts Only Abstract / Description: Multistage crystallization has been used for resolution of the racemic mixture of citalopram to obtain pure S-citalopram. The racemate was converted to a diasteromeric salt pair using (+)-O,O′-di-p-toluoyl-d-tartaric acid, (+)DTT, as a resolving agent. The obtained salts involved solid solutions almost within the entire range of the crystalline phase composition, which excluded the possibility of a single-stage resolution. Therefore, a multistep crystallization technique was employed that allowed enrichment of the racemate with the desired diastereomer in the liquid phase. Moreover, a procedure for restoring the 1:1 composition of the depleted solid phase has been developed. The procedure was based on formation of a diasteromeric salt pair with the opposite enantiomer of the resolving agent, i.e., (−)DTT. Copyright © 2012 American Chemical Society External Publication Status: published Document Type: Article Communicated by: Andreas Seidel-Morgenstern Affiliations: MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering External Affiliations: University of Rzeszów, Chair of Chemistry and Food Toxicology, Rzeszów, Poland Otto-von-Guericke-Universität Magdeburg, Institut für Verfahrenstechnik, 39106 Magdeburg, Germany Rzeszów University of Technology, Department of Chemical and Process Engineering, Rzeszów, Poland Identifiers: URL:http://dx.doi.org/10.1021/cg300166g The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.