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          Institute: MPI für Evolutionsbiologie     Collection: Evolutionary ecology     Display Documents

ID: 610633.0, MPI für Evolutionsbiologie / Evolutionary ecology
Divergent selection on locally adapted major histocompatibility complex immune genes experimentally proven in the field
Authors:Eizaguirre, Christophe; Lenz, Tobias L.; Kalbe, Martin; Milinski, Manfred
Date of Publication (YYYY-MM-DD):2012-07
Title of Journal:Ecology Letters
Issue / Number:7
Start Page:723
End Page:731
Review Status:not specified
Audience:Not Specified
Abstract / Description:Although crucial for the understanding of adaptive evolution, genetically resolved examples of local adaptation
are rare. To maximize survival and reproduction in their local environment, hosts should resist their
local parasites and pathogens. The major histocompatibility complex (MHC) with its key function in parasite
resistance represents an ideal candidate to investigate parasite-mediated local adaptation. Using replicated
field mesocosms, stocked with second-generation lab-bred three-spined stickleback hybrids of a lake
and a river population, we show local adaptation of MHC genotypes to population-specific parasites, independently
of the genetic background. Increased allele divergence of lake MHC genotypes allows lake fish
to fight the broad range of lake parasites, whereas more specific river genotypes confer selective advantages
against the less diverse river parasites. Hybrids with local MHC genotype gained more body weight and
thus higher fitness than those with foreign MHC in either habitat, suggesting the evolutionary significance
of locally adapted MHC genotypes.
Free Keywords:adaptive radiation; host–parasite coevolution; local adaptation; major histocompatibility complex
External Publication Status:published
Document Type:Article
Communicated by:Brigitte Lechner
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsökologie
External Affiliations:Department of Evolutionary Ecology of Marine Fishes, GEOMAR Helmholtz Center for Ocean Research, Kiel, 24105, Germany;
Present address Division of Genetics, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 02115, USA
Identifiers:ISSN:1461-023x (print) [ID-No:1]
ISSN:1461-0248 (online) [ID-No2:]
DOI:10.1111/j.1461-0248.2012.01791.x [ID-No:3]
LOCALID:2921/S 39266 [Listen-Nummer/S-Nummer]
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