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          Institute: MPI für Evolutionsbiologie     Collection: Evolutionary genetics     Display Documents



  history
ID: 610669.0, MPI für Evolutionsbiologie / Evolutionary genetics
The genomic basis of adaptive evolution in threespine sticklebacks
Authors:Jones, Felicity C.; Grabherr, Manfred G.; Chan, Yingguang Frank; Russell, Pamela; Mauceli, Evan; Johnson, Jeremy; Swofford, Ross; Pirun, Mono; Zody, Michael C.; White, Simon; Birney, Ewan; Searle, Stephen; Schmutz, Jeremy; Grimwood, Jane; Dickson, Mark C.; Myers, Richard M.; Miller, Craig T.; Summers, Brian R.; Knecht, Anne K.; Brady, Shannon D.; Zhang, Haili; Pollen, Alex A.; Howes, Timothy; Amemiya, Chris; Team, Broad Institute Genome Sequencing Platform & Whole Genome Assembly; Lander, Eric S.; Di Palma, Federica; Lindblad-Toh, Kerstin; Kingsley, David M.
Language:English
Date of Publication (YYYY-MM-DD):2012-04-05
Title of Journal:Nature
Volume:484
Issue / Number:7392
Start Page:55
End Page:61
Review Status:not specified
Audience:Not Specified
Abstract / Description:Marine stickleback fish have colonized and adapted to thousands of streams and lakes formed since the last ice age,
providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in
nature. Here we develop a high-quality reference genome assembly for threespine sticklebacks. By sequencing the
genomes of twenty additional individuals from a global set of marine and freshwater populations, we identify a
genome-wide set of loci that are consistently associated with marine–freshwater divergence. Our results indicate
that reuse of globally shared standing genetic variation, including chromosomal inversions, has an important role in
repeated evolution of distinct marine and freshwater sticklebacks, and in the maintenance of divergent ecotypes during
early stages of reproductive isolation. Both coding and regulatory changes occur in the set of loci underlying marine–
freshwater evolution, but regulatory changes appear to predominate in this well known example of repeated adaptive
evolution in nature.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Brigitte Lechner
Affiliations:MPI für Evolutionsbiologie/Abt. Evolutionsgenetik
External Affiliations:Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford California 94305, USA; Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge Massachusetts 02142, USA; Science for Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala 751 23, Sweden; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK; HudsonAlpha Institute for Biotechnology, 601 Genome Way, Huntsville, Alabama 35806, USA; Department of Molecular Genetics, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle Washington 98101, USA; Howard
Hughes Medical Institute, Stanford University, Stanford, California 94305, USA; Children’s Hospital Boston, Genetic Diagnostic Lab, 300 Longwood Avenue, Boston, Massachusetts 02115, USA (E.M.); Bioinformatics Core, Zuckerman Research Center, New York, New York 10065, USA(M.P.); Department of Molecular & Cell Biology, 142 LSA 3200, University of California, Berkeley, California 94720, USA (C.T.M.)
Identifiers:ISSN:0028-0836 (print) [ID-No:1]
ISSN:1476-4687 (online) [ID-No:2]
DOI:10.1038/nature10944 [ID-No:3]
LOCALID:2917/S 39262 [Listen-Nummer/S-Nummer]
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