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          Institute: MPI für molekulare Physiologie     Collection: Abteilung IV - Chemische Biologie     Display Documents



ID: 6108.0, MPI für molekulare Physiologie / Abteilung IV - Chemische Biologie
Chemo-enzymatic synthesis of the C₁₅-C₂₃ unit of leptomycin B
Authors:Scheck, Michael; Waldmann, Herbert
Language:English
Research Context:Chemoenzymatic synthesis
Date of Publication (YYYY-MM-DD):2002-05-07
Title of Journal:Canadian Journal of Chemistry - Revue Canadienne de Chimie
Journal Abbrev.:Can. J. Chem. - Rev. Can. Chim.
Volume:80
Issue / Number:6
Start Page:571
End Page:576
Sequence Number of Article:1
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The asymmetric synthesis of the C-15-C-23 unit of Leptomycin B (LMB) is described. All four stereocenters of the C-15-C-23 unit were prepared from one building block exhibiting only one stereocenter. This building block was synthesized via either an enzymatic transformation or starting from a chiral reagent.
Free Keywords:leptomycin; natural product synthesis; enzymatic transformation; Aldol reaction; Pseudomonas fluorescence lipase (PFL)
External Publication Status:published
Document Type:Article
Affiliations:MPI für molekulare Physiologie/Abteilung IV - Chemische Biologie/AG Prof. Dr. Herbert Waldmann
External Affiliations:Univ Dortmund, Inst Organ Chem, D-44227 Dortmund, Germany
Identifiers:URL:http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?_... [pdf version of this article]
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