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          Institute: MPI für Infektionsbiologie     Collection: Department of Immunology     Display Documents

ID: 611187.0, MPI für Infektionsbiologie / Department of Immunology
Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?
Authors:Ottenhoff, Tom H. M.; Kaufmann, Stefan H. E.
Date of Publication (YYYY-MM-DD):2012-05
Title of Journal:PLoS Pathogens
Journal Abbrev.:PLoS Pathog.
Issue / Number:5
Sequence Number of Article:e1002607
Copyright:Copyright Ottenhoff, Kaufmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:In this review we discuss recent progress in the development, testing, and clinical evaluation of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has been made in TB vaccine research and development: from a pipeline virtually empty of new TB candidate vaccines in the early 1990s, to an era in which a dozen novel TB vaccine candidates have been and are being evaluated in human clinical trials. In addition, innovative approaches are being pursued to further improve existing vaccines, as well as discover new ones. Thus, there is good reason for optimism in the field of TB vaccines that it will be possible to develop better vaccines than BCG, which is still the only vaccine available against TB.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Beate Löhr
Affiliations:MPI für Infektionsbiologie/Department of Immunology
External Affiliations:[Ottenhoff, Tom H. M.] Leiden Univ, Med Ctr, Dept Infect Dis, Leiden, Netherlands.
Identifiers:ISI:000305322900001 [ID No:1]
ISSN:1553-7374 [ID No:2]
DOI:10.1371/journal.ppat.1002607 [ID No:3]
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