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| ID:
619130.0,
MPI für Infektionsbiologie / Department of Immunology |
| Biomarkers of Inflammation, Immunosuppression and Stress with Active Disease Are Revealed by Metabolomic Profiling of Tuberculosis Patients |
| Authors: | Weiner, January, 3rd; Parida, Shreemanta K.; Maertzdorf, Jeroen; Black, Gillian F.; Repsilber, Dirk; Telaar, Anna; Mohney, Robert P.; Arndt-Sullivan, Cordelia; Ganoza, Christian A.; Faé, Kellen C.; Walzl, Gerhard; Kaufmann, Stefan H. E. | | Date of Publication (YYYY-MM-DD): | 2012-07-23 | | Title of Journal: | PLoS ONE | | Volume: | 7 | | Issue / Number: | 7 | | Sequence Number of Article: | e40221 | | Copyright: | 2012 Weiner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | | Review Status: | not specified | | Audience: | Experts Only | | Abstract / Description: | Although tuberculosis (TB) causes more deaths than any other pathogen, most infected individuals harbor the pathogen without signs of disease. We explored the metabolome of >400 small molecules in serum of uninfected individuals, latently infected healthy individuals and patients with active TB. We identified changes in amino acid, lipid and nucleotide metabolism pathways, providing evidence for anti-inflammatory metabolomic changes in TB. Metabolic profiles indicate increased activity of indoleamine 2,3 dioxygenase 1 (IDO1), decreased phospholipase activity, increased abundance of adenosine metabolism products, as well as indicators of fibrotic lesions in active disease as compared to latent infection. Consistent with our predictions, we experimentally demonstrate TB-induced IDO1 activity. Furthermore, we demonstrate a link between metabolic profiles and cytokine signaling. Finally, we show that 20 metabolites are sufficient for robust discrimination of TB patients from healthy individuals. Our results provide specific insights into the biology of TB and pave the way for the rational development of metabolic biomarkers for TB. | | External Publication Status: | published | | Document Type: | Article | | Version Comment: | Automatic journal name synchronization |
| Communicated by: | Beate Löhr | | Affiliations: | MPI für Infektionsbiologie/Department of Immunology
| | Identifiers: | ISI:000306687700009 [ID No:1]
ISSN:1932-6203 [ID No:2]
URI:10.1371/journal.pone.0040221 [ID No:3] | |
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