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Home Search Quick Search Advanced Fulltext Browse Collections Persons My eDoc Session History Login Name: Password: Documentation Help Support Wiki Direct access to document ID:	Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents   history ID: 636033.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel) Natural variation in biogenesis efficiency of individual Arabidopsis thaliana microRNAs Authors: Todesco, M.; Balasubramanian, S.; Cao, J.; Ott, F.; Sureshkumar, S.; Schneeberger, K.; Meyer, R. C.; Altmann, T.; Weigel, D. Date of Publication (YYYY-MM-DD): 2012-01-24 Title of Journal: Curr Biol Volume: 22 Issue / Number: 2 Start Page: 166 End Page: 170 Review Status: not specified Audience: Not Specified Abstract / Description: Like protein-coding genes, loci that produce microRNAs (miRNAs) are generally considered to be under purifying selection, consistent with miRNA polymorphisms being able to cause disease. Nevertheless, it has been hypothesized that variation in miRNA genes may contribute to phenotypic diversity. Here we demonstrate that a naturally occurring polymorphism in the MIR164A gene affects leaf shape and shoot architecture in Arabidopsis thaliana, with the effects being modified by additional loci in the genome. A single base pair substitution in the miRNA complementary sequence alters the predicted stability of the miRNA:miRNA( *) duplex. It thereby greatly reduces miRNA accumulation, probably because it interferes with precursor processing. We demonstrate that this is not a rare exception and that natural strains of Arabidopsis thaliana harbor dozens of similar polymorphisms that affect processing of a wide range of miRNA precursors. Our results suggest that natural variation in miRNA biogenesis resulting from cis mutations is a common contributor to phenotypic variation in plants. Free Keywords: Alleles; Arabidopsis/*physiology; MicroRNAs/*physiology; Plant Leaves/growth & development; Plant Shoots/growth & development; Polymorphism, Genetic; RNA, Plant/*physiology External Publication Status: published Document Type: Article Affiliations: MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel) External Affiliations: %G eng Identifiers: ISSN:1879-0445 (Electronic) 0960-9822 (Linking) %R 10.1... [ID No:1] URL:http://www.ncbi.nlm.nih.gov/pubmed/22206705 [ID No:2] The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.