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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents



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ID: 636042.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
Fitness of Arabidopsis thaliana mutation accumulation lines whose spontaneous mutations are known
Authors:Rutter, M. T.; Roles, A.; Conner, J. K.; Shaw, R. G.; Shaw, F. H.; Schneeberger, K.; Ossowski, S.; Weigel, D.; Fenster, C. B.
Date of Publication (YYYY-MM-DD):2012-07
Title of Journal:Evolution
Volume:66
Issue / Number:7
Start Page:2335
End Page:2339
Review Status:not specified
Audience:Not Specified
Abstract / Description:Despite the fundamental importance of mutation to the evolutionary process, we have little knowledge of the direct consequences of specific spontaneous mutations to the fitness of the organism. Combining results of whole-genome sequencing with repeated field assays of survival and reproduction, we quantify the combined effects on fitness of spontaneous mutations identified in Arabidopsis thaliana. We demonstrate that the effects are beneficial, deleterious, or neutral depending on the environmental context. Some lines, bearing mutations disrupting known loci, differ strongly in fitness from the founder or premutation genotype. Those effects vary across environments, for example, a line with a major deletion spanning a transcription factor gene expressed lower fitness than the founder under most conditions but exceeded the founder's fitness in one environment. The large contribution of genotype by environment interaction (G x E) to mutation effects on fitness implies spatial and/or temporal variation in selection on new mutations and could contribute to the maintenance of standing genetic variation.
Free Keywords:Arabidopsis/*genetics; *Environment; *Genetic Fitness; Genetic Variation; Longevity; *Mutation; Phenotype; Reproduction; Seasons; Selection, Genetic
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
External Affiliations:%G eng
Identifiers:ISSN:1558-5646 (Electronic) 0014-3820 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/22759306 [ID No:2]
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