| ID:
638078.0,
MPI für medizinische Forschung / Jahrbuch 2012 |
| Enzyme−Substrate Complementarity Governs Access to a Cationic Reaction Manifold in the P450 BM3−Catalysed Oxidation of Cyclopropyl Fatty Acids |
| Translation of Title: | Enzyme−Substrate Complementarity Governs Access to a Cationic Reaction Manifold in the P450 BM3−Catalysed Oxidation of Cyclopropyl Fatty Acids |
| Authors: | Cryle, Max; Hayes, Patricia Y.; De Voss, James J. |
| Language: | English |
| Date of Publication (YYYY-MM-DD): | 2012-12-07 |
| Title of Journal: | Chemistry  A European Journal |
| Journal Abbrev.: | Chemistry − A European Journal |
| Volume: | 18 |
| Issue / Number: | 50 |
| Start Page: | 15994 |
| End Page: | 15999 |
| Review Status: | Peer-review |
| Audience: | Experts Only |
| Intended Educational Use: | No |
| Abstract / Description: | The products of cytochrome P450BM3−catalysed oxidation of cyclopropyl−containing dodecanoic acids are consistent with the presence of a cationic reaction intermediate, which results in efficient dehydrogenation of the rearranged probes by the enzyme. These results highlight the importance of enzyme−substrate complementarity, with a cationic intermediate occurring only when the probes used begin to diverge from ideal substrates for this enzyme. This also aids in reconciling literature reports supporting the presence of cationic intermediates with certain cytochrome P450 enzyme/substrate pairs |
| Free Keywords: | carbocation;
CYP102A1;
cytochromes;
enzyme catalysis;
oxidation |
| External Publication Status: | published |
| Document Type: | Article |
| Version Comment: | Automatic journal name synchronization |
| Communicated by: | Wulf Kaiser |
| Affiliations: | MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen/Heme and Flavin Enzymes
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen/Cytochrome P450
|
| Identifiers: | LOCALID:7881
URI:http%3A%2F%2Fonlinelibrary.wiley.com%2Fdoi%2F10.10...
URI:http%3A%2F%2Fonlinelibrary.wiley.com%2Fdoi%2F10.10...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23109...
DOI:10.1002%2Fchem.201203035 |
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