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          Institute: MPI für medizinische Forschung     Collection: Jahrbuch 2012     Display Documents



ID: 638094.0, MPI für medizinische Forschung / Jahrbuch 2012
Layer−Specific Targeting of Direction−Selective Neurons in the Zebrafish Optic Tectum
Translation of Title:Layer−Specific Targeting of Direction−Selective Neurons in the Zebrafish Optic Tectum
Authors:Gabriel, Jens Peter; Trivedi, Chintan; Maurer, Colette; Ryu, Soojin; Bollmann, Johann H.
Language:English
Date of Publication (YYYY-MM-DD):2012-12-20
Title of Journal:Neuron
Journal Abbrev.:Neuron
Volume:76
Issue / Number:6
Start Page:117
End Page:1160
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Direction selectivity (DS) is an important neuronal property in the visual system, but how DS is generated beyond the retina remains controversial. Here, we report a close correspondence between the preferred direction (PD) and the morphology of DS cells in the optic tectum. Ca2+ imaging in cells expressing the genetically encoded Ca2+ indicator GCaMP3 and multiphoton−targeted patch−clamp recordings allowed us to compare structure and function in single neurons. The arbors of differently tuned cell types showed stereotypic differences in shape and laminar profile within the tectal neuropil. Excitatory synaptic inputs were directionally tuned and matched the PD of spike output in these cells, while inhibitory inputs were selective for nonpreferred directions. Functional Ca2+ imaging in afferent axons showed a matching laminar distribution of DS presynaptic activity. Hence, different directions are represented in different layers, which suggests a simple mechanism for how tectal neurons acquire directional tuning in a nascent circuit
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Biomedizinische Optik
MPI für medizinische Forschung/Abteilung Zellphysiologie/Synaptische Transmission - molekulare Mechanismen und strukturelle Organisation
MPI für medizinische Forschung/Abteilung Biomedizinische Optik/Gruppe Johann Bollmann
MPI für medizinische Forschung/Max-Planck-Forschungsgruppe Entwicklungsgenetik des Nervensystems (Soojin Ryu)
Identifiers:LOCALID:7856
URI:http%3A%2F%2Fpdn.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fdx.doi.org%2F
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23259...
DOI:10.1016%2Fj.neuron.2012.12.003
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