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          Institute: MPI für medizinische Forschung     Collection: Jahrbuch 2012     Display Documents



ID: 638103.0, MPI für medizinische Forschung / Jahrbuch 2012
A−to−I RNA Editing: Effects on Proteins Key to Neural Excitability
Translation of Title:A−to−I RNA Editing: Effects on Proteins Key to Neural Excitability
Authors:Rosenthal, Joshua J. C.; Seeburg, Peter H.
Language:English
Date of Publication (YYYY-MM-DD):2012-05-10
Title of Journal:Neuron
Journal Abbrev.:Neuron
Volume:74
Issue / Number:3
Start Page:432
End Page:439
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:RNA editing by adenosine deamination is a process used to diversify the proteome. The expression of ADARs, the editing enzymes, is ubiquitous among true metazoans, and so adenosine deamination is thought to be universal. By changing codons at the level of mRNA, protein function can be altered, perhaps in response to physiological demand. Although the number of editing sites identified in recent years has been rising exponentially, their effects on protein function, in general, are less well understood. This review assesses the state of the field and highlights particular cases where the biophysical alterations and functional effects caused by RNA editing have been studied in detail
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Identifiers:LOCALID:7825
URI:http%3A%2F%2Fpdn.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fdx.doi.org%2F10.1016%2Fj.neuron.2012....
URI:http%3A%2F%2Fwww.cell.com%2Fneuron%2Fabstract%2FS0...
DOI:10.1016%2Fj.neuron.2012.04.010
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