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          Institute: MPI für medizinische Forschung     Collection: Jahrbuch 2012     Display Documents

ID: 638107.0, MPI für medizinische Forschung / Jahrbuch 2012
Femtosecond dark−field imaging with an X−ray free electron laser
Translation of Title:Femtosecond dark−field imaging with an X−ray free electron laser
Authors:Martin, Andrew V.; Loh, Ne−Te Duane; Hampton, Christina Y.; Sierra, Raymond G.; Wang, Fenglin; Aquila, Andrew; Bajt, Saša; Barthelmess, Miriam; Bostedt, Christoph; Bozek, John D.; Coppola, Nicola; Epp, Sascha W.; Erk, Benjamin; Fleckenstein, Holger; Foucar, Lutz; Frank, Matthias; Graafsma, Heinz; Gumprecht, Lars; Hartmann, Andreas; Hartmann, Robert; Hauser, Gunter; Hirsemann, Helmut; Holl, Peter; Kassemeyer, Stephan; Kimmel, Nils; Liang, Mengning; Lomb, Lukas; Maia, Filipe R. N. C.; Marchesini, Stefano; Nass, Karol; Pedersoli, Emanuele; Reich, Christian; Rolles, Daniel; Rudek, Benedikt; Rudenko, Artem; Schulz, Joachim; Shoeman, Robert L.; Soltau, Heike; Starodub, Dmitri; Steinbrener, Jan; Stellato, Francesco; Strüder, Lothar; Ullrich, Joachim; Weidenspointner, Georg; White, Thomas A.; Wunderer, Cornelia B.; Barty, Anton; Schlichting, Ilme; Bogan, Michael J.; Chapman, Henry N.
Date of Publication (YYYY-MM-DD):2012-06-04
Title of Journal:Optics Express
Journal Abbrev.:Optics Express
Issue / Number:12
Start Page:13501
End Page:13512
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The emergence of femtosecond diffractive imaging with X−ray lasers has enabled pioneering structural studies of isolated particles, such as viruses, at nanometer length scales. However, the issue of missing low frequency data significantly limits the potential of X−ray lasers to reveal sub−nanometer details of micrometer−sized samples. We have developed a new technique of dark−field coherent diffractive imaging to simultaneously overcome the missing data issue and enable us to harness the unique contrast mechanisms available in dark−field microscopy. Images of airborne particulate matter (soot) up to two microns in length were obtained using single−shot diffraction patterns obtained at the Linac Coherent Light Source, four times the size of objects previously imaged in similar experiments. This technique opens the door to femtosecond diffractive imaging of a wide range of micrometer−sized materials that exhibit irreproducible complexity down to the nanoscale, including airborne particulate matter, small cells, bacteria and gold−labeled biological samples
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biophysik
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen/Heme and Flavin Enzymes
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen/Analytical Protein Biochemistry
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen/Coherent diffractive imaging
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