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          Institute: MPI für medizinische Forschung     Collection: Jahrbuch 2012     Display Documents



ID: 638110.0, MPI für medizinische Forschung / Jahrbuch 2012
Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination
Translation of Title:Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination
Authors:Saab, Aiman S.; Neumeyer, Alexander; Jahn, Hannah M.; Cupido, Alexander; Šimek, Antonia A. M.; Boele, Henk−Jan; Scheller, Anja; Le Meur, Karim; Götz, Magdalena; Monyer, Hannah; Sprengel, Rolf; Rubio, Maria E.; Deitmer, Joachim W.; De Zeeuw, Chris I.; Kirchhoff, Frank
Language:English
Date of Publication (YYYY-MM-DD):2012-08-10
Title of Journal:Science
Journal Abbrev.:Science
Volume:337
Issue / Number:6095
Start Page:749
End Page:753
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial cells (BG) express α−amino−3−hydroxy−5−methyl−4−isoxazolepropionic acid (AMPA)−type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. Using conditional gene inactivation, we found that the majority of cerebellar GluA1/A4−type AMPARs are expressed in BG. In young mice, deletion of BG AMPARs resulted in retraction of glial appendages from Purkinje cell (PC) synapses, increased amplitude and duration of evoked PC currents, and a delayed formation of glutamatergic synapses. In adult mice, AMPAR inactivation also caused retraction of glial processes. The physiological and structural changes were accompanied by behavioral impairments in fine motor coordination. Thus, BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7816
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcontent%2Fearly%...
URI:http%3A%2F%2Fwww.sciencemag.org%2Fcontent%2Fearly%...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22767...
DOI:10.1126%2Fscience.1221140
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