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          Institute: MPI für medizinische Forschung     Collection: Jahrbuch 2012     Display Documents



ID: 638138.0, MPI für medizinische Forschung / Jahrbuch 2012
In vivo protein crystallization opens new routes in structural biology
Translation of Title:In vivo protein crystallization opens new routes in structural biology
Authors:Koopmann, Rudolf; Cupelli, Karolina; Redecke, Lars; Nass, Karol; DePonte, Daniel P.; White, Thomas A.; Stellato, Francesco; Rehders, Dirk; Liang, Mengning; Andreasson, Jakob; Aquila, Andrew; Bajt, Saša; Barthelmess, Miriam; Barty, Anton; Bogan, Michael J.; Bostedt, Christoph; Boutet, Sébastien; Bozek, John D.; Caleman, Carl; Coppola, Nicola; Davidsson, Jan; Doak, R. Bruce; Ekeberg, Tomas; Epp, Sascha W.; Erk, Benjamin; Fleckenstein, Holger; Foucar, Lutz; Graafsma, Heinz; Gumprecht, Lars; Hajdu, Janos; Hampton, Christina. Y; Hartmann, Andreas; Hartmann, Robert; Hauser, Günter; Hirsemann, Helmut; Holl, Peter; Hunter, Mark S.; Kassemeyer, Stephan; Kirian, Richard A.; Lomb, Lukas; Maia, Filipe R. N. C.; Kimmel, Nils; Martin, Andrew V.; Messerschmidt, Marc; Reich, Christian; Rolles, Daniel; Rudek, Benedikt; Rudenko, Artem; Schlichting, Ilme; Schulz, Joachim; Seibert, M. Marvin; Shoeman, Robert L.; Sierra, Raymond G.; Soltau, Heike; Stern, Stephan; Strüder, Lothar; Timneanu, Nicusor; Ullrich, Joachim; Wang, Xiaoyu; Weidenspointner, Georg; Weierstall, Uwe; Williams, Garth J.; Wunderer, Cornelia B.; Fromme, Petra; Spence, John C. H.; Stehle, Thilo; Chapman, Henry N.; Betzel, Christian; Duszenko, Michael
Language:English
Date of Publication (YYYY-MM-DD):2012-01-29
Title of Journal:Nature Methods
Journal Abbrev.:Nature Methods
Volume:9
Issue / Number:3
Start Page:259
End Page:262
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Protein crystallization in cells has been observed several times in nature. However, owing to their small size these crystals have not yet been used for X−ray crystallographic analysis.
We prepared nano−sized in vivo−grown crystals of Trypanosoma brucei enzymes and applied the emerging method of free−electron laser−based serial femtosecond crystallography to record interpretable diffraction data. This combined approach will open new opportunities in structural systems biology
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biophysik
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen/Heme and Flavin Enzymes
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen/Analytical Protein Biochemistry
MPI für medizinische Forschung/Abteilung Biomolekulare Mechanismen/Coherent diffractive imaging
Identifiers:LOCALID:7761
URI:http%3A%2F%2Fwww.nature.com%2Fnmeth%2Fjournal%2Fv9...
URI:http%3A%2F%2Fwww.nature.com%2Fnmeth%2Fjournal%2Fv9...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22286...
DOI:10.1038%2Fnmeth.1859
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