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          Institute: MPI für medizinische Forschung     Collection: Jahrbuch 2012     Display Documents



ID: 638142.0, MPI für medizinische Forschung / Jahrbuch 2012
Structural neurobiology: missing link to a mechanistic understanding of neural computation
Translation of Title:Structural neurobiology: missing link to a mechanistic understanding of neural computation
Authors:Denk, Winfried; Briggman, Kevin; Helmstaedter, Moritz
Language:English
Date of Publication (YYYY-MM-DD):2012-02-22
Title of Journal:Nature Reviews Neuroscience
Journal Abbrev.:Nat. Rev. Neurosci.
Volume:13
Issue / Number:5
Start Page:351
End Page:358
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:High−resolution, comprehensive structural information is often the final arbiter between competing mechanistic models of biological processes, and can serve as inspiration for new hypotheses. In molecular biology, definitive structural data at atomic resolution are available for many macromolecules; however, information about the structure of the brain is much less complete, both in scope and resolution. Several technical developments over the past decade, such as serial block−face electron microscopy and trans−synaptic viral tracing, have made the structural biology of neural circuits conceivable: we may be able to obtain the structural information needed to reconstruct the network of cellular connections for large parts of, or even an entire, mouse brain within a decade or so. Given that the brain's algorithms are ultimately encoded by this network, knowing where all of these connections are should, at the very least, provide the data needed to distinguish between models of neural computation
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Biomedizinische Optik
MPI für medizinische Forschung/Abteilung Zellphysiologie/Kortikale Schaltkreise
MPI für medizinische Forschung/Abteilung Biomedizinische Optik/Gruppe Moritz Helmstaedter
Identifiers:LOCALID:7756
URI:http%3A%2F%2Fwww.nature.com%2Fnrn%2Fjournal%2Fvaop...
URI:http%3A%2F%2Fwww.nature.com%2Fnrn%2Fjournal%2Fvaop...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F22353...
DOI:10.1038%2Fnrn3169
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