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          Institute: MPI für medizinische Forschung     Collection: Jahrbuch 2012     Display Documents



ID: 638162.0, MPI für medizinische Forschung / Jahrbuch 2012
Alpha−1 Adrenergic Receptors Gate Rapid Orientation−Specific Reduction in Visual
Discrimination
Translation of Title:Alpha−1 Adrenergic Receptors Gate Rapid Orientation−Specific Reduction in Visual
Discrimination
Authors:Trevino, Mario; Frey, Sebastian; Köhr, Georg
Language:English
Date of Publication (YYYY-MM-DD):2012-11-01
Title of Journal:Cerebral Cortex
Journal Abbrev.:Cereb. Cortex
Volume:22
Issue / Number:11
Start Page:2529
End Page:2541
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Prolonged imbalance in sensory experience leads to dramatic
readjustments in cortical representation. Neuromodulatory systems
play a critical role in habilitating experience−induced plasticity and
regulate memory processes in vivo. Here, we show that a brief
period of intense patterned visual stimulation combined with
systemic activation of alpha−1 adrenergic neuromodulator receptors
(a1−ARs) leads to a rapid, reversible, and NMDAR−dependent
depression of AMPAR−mediated transmission from ascending
inputs to layer II/III pyramidal cells in the visual cortex of young
and adult mice. The magnitude of this form of a1−AR long−term
depression (LTD), measured ex vivo with miniature EPSC recordings,
is graded by the number of orientations used during visual
experience. Moreover, behavioral tests of visual function following
the induction of a1−AR LTD reveal that discrimination accuracy of
sinusoidal drifting gratings is selectively reduced at high spatial
frequencies in a reversible, orientation−specific, and NMDARdependent
manner. Thus, a1−ARs enable rapid cortical synaptic
depression which correlates with an orientation−specific decrease
in visual discrimination. These findings contribute to our understanding
of how adrenergic receptors interact with neuronal
networks in response to changes in active sensory experience to
produce adaptive behavior
Free Keywords:experience−induced plasticity, mEPSC, mouse, NMDA
receptors, visual cortex
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Georg Köhr
Identifiers:LOCALID:7709
URI:http%3A%2F%2Fcercor.oxfordjournals.org%2Fcontent%2...
URI:http%3A%2F%2Fcercor.oxfordjournals.org%2Fcontent%2...
URI:http%3A%2F%2Fcercor.oxfordjournals.org%2Fcontent%2...
DOI:10.1093%2Fcercor%2Fbhr333
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