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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2012-arch     Display Documents



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ID: 645166.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2012-arch
GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.
Authors:Scolz, Massimilano; Widlund, Per; Piazza, Silvano; Bublik, Debora Rosa; Reber, Simone; Peche, Leticia Y; Ciani, Yari; Hubner, Nina; Isokane, Mayumi; Monte, Martin; Ellenberg, Jan; Hyman, Anthony; Schneider, Claudio; Bird, Alexander W.
Date of Publication (YYYY-MM-DD):2012
Title of Journal:PLoS ONE
Volume:7
Issue / Number:12
Sequence Number of Article:e51259
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs) are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:5203
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