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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2012-arch     Display Documents



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ID: 645195.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2012-arch
Combined RNAi and localization for functionally dissecting long non-coding RNAs
Authors:Chakraborty, Debojyoti; Kappei, Dennis; Theis, Mirko; Nitzsche, Anja; Ding, Li; Paszkowski-Rogacz, Maciej; Surendranath, Vineeth; Berger, Nicolas; Schulz, Herbert; Saar, Kathrin; Hubner, Norbert; Buchholz, Frank
Date of Publication (YYYY-MM-DD):2012
Title of Journal:Nature Methods
Volume:9
Issue / Number:4
Start Page:360
End Page:362
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Whereas methods to comprehensively study cellular roles of protein-coding genes are available, techniques to systematically investigate long noncoding RNAs (lncRNAs), which have been implicated in diverse biological pathways, are limited. Here we report combined knockdown and localization analysis of noncoding RNAs (c-KLAN) that merges functional characterization and localization approaches to study lncRNAs. Using this technique we identified transcripts that regulate mouse embryonic stem cell identity.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4649
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