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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2012-arch     Display Documents



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ID: 645268.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2012-arch
RNA-protein interactions in vivo: global gets specific
Authors:Änkö, Minna-Liisa; Neugebauer, Karla M.
Date of Publication (YYYY-MM-DD):2012
Title of Journal:Trends in Biochemical Sciences
Volume:37
Issue / Number:7
Start Page:255
End Page:262
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:RNA-binding proteins (RBPs) impact every process in the cell; they act as splicing and polyadenylation factors, transport and localization factors, stabilizers and destabilizers, modifiers, and chaperones. RNA-binding capacity can be attributed to numerous protein domains that bind a limited repertoire of short RNA sequences. How is specificity achieved in cells? Here we focus on recent advances in determining the RNA-binding properties of proteins in vivo and compare these to in vitro determinations, highlighting insights into how endogenous RNA molecules are recognized and regulated. We also discuss the crucial contribution of structural determinations for understanding RNA-binding specificity and mechanisms.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:4956
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