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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: MPI-CBG Publications 2012-arch     Display Documents

ID: 645335.0, MPI für molekulare Zellbiologie und Genetik / MPI-CBG Publications 2012-arch
Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner.
Authors:Baer, Magdalena M; Palm, Wilhelm; Eaton, Suzanne; Leptin, Maria; Affolter, Markus
Date of Publication (YYYY-MM-DD):2012
Title of Journal:Journal of Cell Science
Issue / Number:Pt 24
Start Page:6038
End Page:6048
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The Drosophila tracheal system is a useful model for dissecting the molecular mechanisms controlling the assembly and expansion of tubular organs. We have identified microsomal triacylglycerol transfer protein (MTP) as a new player involved in the lumen expansion in unicellular tubes. MTP is an endoplasmic reticulum resident protein that can transfer triglycerides and phospholipids between membranes in vitro. MTP lipid transfer activity is crucial for the assembly and secretion of apoB family lipoproteins, which are carriers of lipids between different tissues. Here we describe an unexpected role of MTP in tracheal development, which we postulate to be independent of its known function in lipoprotein secretion. We propose that, in tracheal cells, MTP is involved in regulation of de novo apical membrane delivery to the existing lumen and thus promotes proper expansion of the larval tracheal system.
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:nn
Affiliations:MPI für molekulare Zellbiologie und Genetik
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