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          Institute: MPI für molekulare Biomedizin     Collection: Yearbook 2013     Display Documents



  history
ID: 648317.0, MPI für molekulare Biomedizin / Yearbook 2013
Directing reprogramming to pluripotency by transcription factors
Authors:Adachi, K.; Schöler, H. R.
Date of Publication (YYYY-MM-DD):2012-10
Title of Journal:Curr Opin Genet Dev
Volume:22
Issue / Number:5
Start Page:416
End Page:422
Review Status:Internal review
Audience:Not Specified
Abstract / Description:The pluripotent state is governed by specifically expressed transcription factors forming a highly interconnected regulatory network in concert with more widely expressed transcription factors. The transcriptional network exhibits a hierarchical structure, with a small number of transcription factors playing an essential role in maintaining pluripotency and controlling the more numerous auxiliary transcription factors. When the set of master transcription factors comprising Oct4, Sox2, Klf4, and Myc is expressed ectopically in somatic cells, the transcriptional network is propelled to organize itself in such a way as to support a pluripotent state. These transcription factors play distinct but interdependent roles in remodeling gene expression by influencing the local chromatin status during reprogramming.
Free Keywords:Animals; Chromatin/metabolism; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Humans; Kruppel-Like Transcription Factors/genetics/metabolism; *Nuclear Reprogramming; Octamer Transcription Factor-3/genetics/metabolism; Pluripotent Stem Cells/*metabolism; Proto-Oncogene Proteins c-myc/genetics/metabolism; SOXB1 Transcription Factors/genetics/metabolism; Transcription Factors/genetics/*metabolism
External Publication Status:published
Document Type:Article
Communicated by:keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:%G eng
Identifiers:ISSN:1879-0380 (Electronic) 0959-437X (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/22868173 [ID No:2]
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