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          Institute: MPI für molekulare Biomedizin     Collection: Yearbook 2013     Display Documents



  history
ID: 648318.0, MPI für molekulare Biomedizin / Yearbook 2013
The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis
Authors:Arcangeli, M. L.; Frontera, V.; Bardin, F.; Thomassin, J.; Chetaille, B.; Adams, S.; Adams, R. H.; Aurrand-Lions, M.
Date of Publication (YYYY-MM-DD):2012-11-16
Title of Journal:FEBS Lett
Volume:586
Issue / Number:22
Start Page:4046
End Page:4051
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Metastasis is a major clinical issue and results in poor prognosis for most cancers. The Junctional Adhesion Molecule-C (JAM-C) expressed by B16 melanoma and endothelial cells has been involved in metastasis of tumor cells through homophilic JAM-C/JAM-C trans-interactions. Here, we show that JAM-B expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with JAM-C on tumor cells. We further show that this adhesion molecular pair mediates melanoma cell adhesion to primary Lung Microvascular Endothelial Cells and that it is functional in vivo as demonstrated by the reduced metastasis of B16 cells in Jam-b deficient mice.
Free Keywords:Animals; Cell Adhesion; Cell Adhesion Molecules/genetics/*metabolism; Cell Line, Tumor; Cell Movement; Cells, Cultured; Coculture Techniques; Endothelial Cells/cytology/*metabolism; Female; Flow Cytometry; Immunoglobulins/genetics/*metabolism; Immunohistochemistry; Lung/blood supply/metabolism; Male; Melanoma, Experimental/genetics/*metabolism/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Neoplasm Metastasis; Protein Binding; RNA Interference
External Publication Status:published
Document Type:Article
Communicated by:keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:%G eng
Identifiers:ISSN:1873-3468 (Electronic) 0014-5793 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/23068611 [ID No:2]
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