Please note that eDoc will be permanently shut down in the first quarter of 2021!      Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Biomedizin     Collection: Yearbook 2013     Display Documents



  history
ID: 648322.0, MPI für molekulare Biomedizin / Yearbook 2013
The role of the tec kinase Bruton's tyrosine kinase (Btk) in leukocyte recruitment
Authors:Block, H.; Zarbock, A.
Date of Publication (YYYY-MM-DD):2012-04
Title of Journal:Int Rev Immunol
Volume:31
Issue / Number:2
Start Page:104
End Page:118
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Recruitment of leukocytes into inflamed tissue is a key component of the immune system. The activation of integrins on leukocytes is required for their recruitment into the inflamed tissue. Btk is a cytoplasmic nonreceptor tyrosine kinase belonging to the Tec-kinase family. It plays a key role in B-cell development and function, and recently published studies revealed important roles of Btk in myeloid cells. Btk might be activated through a variety of receptors leading to activation of integrins as the pivotal element in leukocyte recruitment. This review focuses on the role of Btk in B-lymphocyte homing and in neutrophil recruitment.
Free Keywords:Animals; B-Lymphocytes/*immunology; Cell Movement; Humans; Inflammation/*immunology/metabolism; Lymphocyte Activation/*immunology; Mice; Neutrophil Infiltration/*immunology; Protein-Tyrosine Kinases/*metabolism; Signal Transduction
External Publication Status:published
Document Type:Article
Communicated by:keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:%G eng
Identifiers:ISSN:1563-5244 (Electronic) 0883-0185 (Linking) %R 10.3... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/22449072 [ID No:2]
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.