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          Institute: MPI für molekulare Biomedizin     Collection: Yearbook 2013     Display Documents



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ID: 648324.0, MPI für molekulare Biomedizin / Yearbook 2013
Chemokine signaling directs trunk lymphatic network formation along the preexisting blood vasculature
Authors:Cha, Y. R.; Fujita, M.; Butler, M.; Isogai, S.; Kochhan, E.; Siekmann, A. F.; Weinstein, B. M.
Date of Publication (YYYY-MM-DD):2012-04-17
Title of Journal:Dev Cell
Volume:22
Issue / Number:4
Start Page:824
End Page:836
Review Status:Internal review
Audience:Not Specified
Abstract / Description:The lymphatic system is crucial for fluid homeostasis, immune responses, and numerous pathological processes. However, the molecular mechanisms responsible for establishing the anatomical form of the lymphatic vascular network remain largely unknown. Here, we show that chemokine signaling provides critical guidance cues directing early trunk lymphatic network assembly and patterning. The chemokine receptors Cxcr4a and Cxcr4b are expressed in lymphatic endothelium, whereas chemokine ligands Cxcl12a and Cxcl12b are expressed in adjacent tissues along which the developing lymphatics align. Loss- and gain-of-function studies in zebrafish demonstrate that chemokine signaling orchestrates the stepwise assembly of the trunk lymphatic network. In addition to providing evidence for a lymphatic vascular guidance mechanism, these results also suggest a molecular basis for the anatomical coalignment of lymphatic and blood vessels.
Free Keywords:Animals; Cell Communication; Cells, Cultured; Chemokine CXCL12/genetics/*metabolism; Chemokines, CXC/genetics/*metabolism; Embryo, Nonmammalian/cytology/metabolism; Gene Expression Regulation, Developmental; In Situ Hybridization; Lymphatic System/*physiology; RNA Probes; Receptors, CXCR4/antagonists & inhibitors/genetics/*metabolism; Recombination, Genetic; *Signal Transduction; Zebrafish/embryology/*metabolism; Zebrafish Proteins/antagonists & inhibitors/genetics/*metabolism
External Publication Status:published
Document Type:Article
Communicated by:keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:%G eng
Identifiers:ISSN:1878-1551 (Electronic) 1534-5807 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/22516200 [ID No:2]
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