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          Institute: MPI für molekulare Biomedizin     Collection: Yearbook 2013     Display Documents

ID: 648332.0, MPI für molekulare Biomedizin / Yearbook 2013
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
Authors:Gaengel, K.; Niaudet, C.; Hagikura, K.; Lavina, B.; Muhl, L.; Hofmann, J. J.; Ebarasi, L.; Nystrom, S.; Rymo, S.; Chen, L. L.; Pang, M. F.; Jin, Y.; Raschperger, E.; Roswall, P.; Schulte, D.; Benedito, R.; Larsson, J.; Hellstrom, M.; Fuxe, J.; Uhlen, P.; Adams, R.; Jakobsson, L.; Majumdar, A.; Vestweber, D.; Uv, A.; Betsholtz, C.
Date of Publication (YYYY-MM-DD):2012-09-11
Title of Journal:Dev Cell
Issue / Number:3
Start Page:587
End Page:599
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Angiogenesis, the process by which new blood vessels arise from preexisting ones, is critical for embryonic development and is an integral part of many disease processes. Recent studies have provided detailed information on how angiogenic sprouts initiate, elongate, and branch, but less is known about how these processes cease. Here, we show that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability. Loss of S1PR1 leads to increased endothelial cell sprouting and the formation of ectopic vessel branches. Conversely, S1PR1 signaling inhibits angiogenic sprouting and enhances cell-to-cell adhesion. This correlates with inhibition of vascular endothelial growth factor-A (VEGF-A)-induced signaling and stabilization of vascular endothelial (VE)-cadherin localization at endothelial junctions. Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses.
Free Keywords:Animals; Antigens, CD/*metabolism; Cadherins/*metabolism; Cells, Cultured; Endothelial Cells/metabolism; Humans; Mice; Mice, Knockout; Mice, Transgenic; *Neovascularization, Physiologic; Receptors, Lysosphingolipid/deficiency/*metabolism; Vascular Endothelial Growth Factor Receptor-2/*metabolism; Zebrafish
External Publication Status:published
Document Type:Article
Communicated by:keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:%G eng
Identifiers:ISSN:1878-1551 (Electronic) 1534-5807 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/22975327 [ID No:2]
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