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          Institute: MPI für molekulare Biomedizin     Collection: Yearbook 2013     Display Documents



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ID: 648334.0, MPI für molekulare Biomedizin / Yearbook 2013
Prospects and challenges of reprogrammed cells in hematology and oncology
Authors:Gross, B.; Pittermann, E.; Reinhardt, D.; Cantz, T.; Klusmann, J. H.
Date of Publication (YYYY-MM-DD):2012-09
Title of Journal:Pediatr Hematol Oncol
Volume:29
Issue / Number:6
Start Page:507
End Page:528
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Induced pluripotent stem cells (iPSCs) have emerged as a promising basis for modeling pediatric genetic disorders, allowing the derivation, study, and genetic correction of disease and patient-specific cell lines in vitro. Similar to embryonic stem cells (ESCs), iPSCs are capable of unlimited in vitro expansion and derivation of many cell types, including hematopoietic stem cells (HSCs). These may not only allow large scale screenings to develop therapeutic compounds, but also help to overcome cross-species barriers of genetically engineered animal models, which do not adequately recapitulate the associated human phenotype. Here, we review the current state and emerging developments of iPSC research, which can be exploited as a tool in modeling pediatric hematopoietic disorders and could lead to new clinical applications in gene and cell therapies.
External Publication Status:published
Document Type:Article
Communicated by:keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:%G eng
Identifiers:ISSN:1521-0669 (Electronic) 0888-0018 (Linking) %R 10.3... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [ID No:2]
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