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          Institute: MPI für molekulare Biomedizin     Collection: Yearbook 2013     Display Documents

ID: 648335.0, MPI für molekulare Biomedizin / Yearbook 2013
Active Wnt proteins are secreted on exosomes
Authors:Gross, J. C.; Chaudhary, V.; Bartscherer, K.; Boutros, M.
Date of Publication (YYYY-MM-DD):2012-10
Title of Journal:Nat Cell Biol
Issue / Number:10
Start Page:1036
End Page:1045
Review Status:Internal review
Audience:Not Specified
Abstract / Description:Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. Recent studies have identified several factors that are required for the secretion of Wnt proteins; however, how Wnts travel in the extracellular space remains a largely unresolved question. Here we show that Wnts are secreted on exosomes both during Drosophila development and in human cells. We demonstrate that exosomes carry Wnts on their surface to induce Wnt signalling activity in target cells. Together with the cargo receptor Evi/WIs, Wnts are transported through endosomal compartments onto exosomes, a process that requires the R-SNARE Ykt6. Our study demonstrates an evolutionarily conserved functional role of extracellular vesicular transport of Wnt proteins.
Free Keywords:Animals; Biological Transport/physiology; Cell Line; Drosophila Proteins/physiology; Drosophila melanogaster/growth & development/metabolism; Endosomes/physiology; Exosomes/*metabolism; Humans; Intracellular Signaling Peptides and Proteins/physiology; SNARE Proteins/physiology; Wnt Proteins/*metabolism; Wnt Signaling Pathway/physiology
External Publication Status:published
Document Type:Article
Communicated by:keuker
Affiliations:MPI für molekulare Biomedizin
External Affiliations:%G eng
Identifiers:ISSN:1476-4679 (Electronic) 1465-7392 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/22983114 [ID No:2]
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