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          Institute: MPI für Hirnforschung     Collection: Neurochemistry (Heinrich Betz)     Display Documents



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ID: 64968.0, MPI für Hirnforschung / Neurochemistry (Heinrich Betz)
Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins
Authors:Birkenfeld, J.; Kartmann, B.; Anliker, B.; Ono, K.; Schlotcke, B.; Betz, H.; Roth, D.
Language:English
Date of Publication (YYYY-MM-DD):2003
Title of Journal:Biochemical and Biophysical Research Communications
Journal Abbrev.:Biochem. Biophys. Res. Commun.
Volume:302
Issue / Number:3
Start Page:526
End Page:533
Review Status:not specified
Audience:Not Specified
Abstract / Description:14-3-3 proteins are ubiquitously expressed proteins which serve as central adaptors in different signal transduction cascades. In this study, yeast two-hybrid screening of a rat brain cDNA library identified a novel gene product termed zetin 1/rBSPRY that interacts with 14-3-3zeta. The zetin 1/rBSPRY gene is ubiquitously expressed in a variety of rat tissues, with highest expression being found in testis. In adult brain, high levels of zetin 1/rBSPRY mRNA were observed in the hippocampus, cereberal cortex, and piriform cortex. Biochemical studies confirmed zetin 1/rBSPRY to interact with 14-3-3zeta. Transient co-transfection in COS 7 cells caused a partial redistribution of zetin 1/rBSPRY into 14-3-3zeta enriched submembranous foci at leading edges. Our results suggest a role for zetin 1/rBSPRY-14-3-3 interactions at specialized submembrane domains. (C) 2003 Elsevier Science (USA). All rights reserved.
Free Keywords:14-3-3 proteins, actin, B-box, SPRY domain, brain expression
Comment of the Author/Creator:Date: 2003, MAR 14
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Hirnforschung/Neurochemistry (Abt.: Betz)
Identifiers:ISI:000181755100016 [ID No:1]
ISSN:0006-291X [ID No:2]
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