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          Institute: MPI für Chemische Physik fester Stoffe     Collection: publications 2013     Display Documents



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ID: 671358.0, MPI für Chemische Physik fester Stoffe / publications 2013
Mineralized self-assembled peptides on 3D laser-made scaffolds: a new route toward 'scaffold on scaffold' hard tissue engineering
Authors:Terzaki, K.; Kalloudi, E.; Mossou, E.; Mitchell, E. P.; Forsyth, V. T.; Rosseeva, E.; Simon, P.; Vamvakaki, M.; Chatzinikolaidou, M.; Mitraki, A.; Farsari, M.
Language:English
Date of Publication (YYYY-MM-DD):2013-12-13
Title of Journal:Biofabrication
Volume:5
Issue / Number:4
Start Page:045002-1
End Page:045002-14
Sequence Number of Article:045002
Review Status:not specified
Audience:Not Specified
Abstract / Description:In this study, we propose a new approach to hard tissue regeneration based on the mineralization of 3D scaffolds made using lasers. To this end, we report the rational design of aspartate-containing self-assembling peptides targeted for calcium binding. We further investigate the suitability of these peptides to support cell attachment and proliferation when coupled on a hybrid organic-inorganic structurable material, and evaluate the response of pre-osteoblastic cells on functionalized 3D scaffolds and material surfaces. Our results show that the mineralized peptide, when immobilized on a hybrid photo-structurable material strongly supports cell adhesion, a proliferation increase after three and seven days in culture, and exhibits a statistically significant increase of biomineralization. We propose this strategy as a 'scaffold on scaffold' approach for hard tissue regeneration.
External Publication Status:published
Document Type:Article
Communicated by:Ina Werner
Affiliations:MPI für chemische Physik fester Stoffe
Identifiers:ISI:000327886100003 [ID No:1]
ISSN:1758-5082 [ID No:2]
DOI:10.1088/1758-5082/5/4/045002
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