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          Institute: MPI für Biophysik     Collection: Abt. Biophysikalische Chemie     Display Documents



ID: 678335.0, MPI für Biophysik / Abt. Biophysikalische Chemie
Proteorhodopsin
Authors:Bamann, Christian; Bamberg, Ernst; Wachtveitl, Josef; Glaubitz, Clemens
Language:English
Date of Publication (YYYY-MM-DD):2014-05
Title of Journal:Biochimica et Biophysica Acta - Bioenergetics
Journal Abbrev.:Biochim. Biophys. Acta
Volume:1837
Issue / Number:5
Start Page:614
End Page:625
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Proteorhodopsins are the most abundant retinal based photoreceptors and their phototrophic function might be relevant in marine ecosystems. Here, we describe their remarkable molecular properties with a special focus on the green absorbing variant. Its distinct features include a high pKa value of the primary proton acceptor stabilized through an interaction with a conserved histidine, a long-range interaction between the cytoplasmic EF loop and the chromophore entailing a particularmode of color tuning and a variable proton pumping vectoriality with complex voltage-dependence. The proteorhodopsin family represents a profound example for structure–function relationships. Especially the development of a biophysical understanding of green proteorhodopsin is an excellent example for the unique opportunities offered by a combined approach of advanced spectroscopic and electrophysiological methods. This article is part of a Special Issue entitled: Retinal Proteins—You can teach an old dog new tricks.
Free Keywords:Photocycle; NMR spectroscopy; Photoisomerization; Charge transfer; Electrophysiology
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für Biophysik/Abteilung Biophysikalische Chemie
External Affiliations:Johann Wolfgang Goethe University, Institute for Physical and Theoretical Chemistry, Max-von-Laue Straße 7, 60438 Frankfurt am Main, Germany
Johann Wolfgang Goethe University, Institute for Biophysical Chemistry & Centre for Biomolecular Magnetic Resonance, Max-von-Laue Straße 9, 60438 Frankfurt am Main, Germany
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