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          Institute: MPI für medizinische Forschung     Collection: Jahbruch 2014_archival     Display Documents



  history
ID: 681437.0, MPI für medizinische Forschung / Jahbruch 2014_archival
Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories
Translation of Title:Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories
Authors:Taylor, Amy M.; Bus, Thorsten; Sprengel, Rolf; Seeburg, Peter H.; Rawlins, John Nicholas P.; Bannerman, David M.
Language:English
Date of Publication (YYYY-MM-DD):2013-12-02
Title of Journal:Philosophical Transactions of the Royal Society of London B
Journal Abbrev.:Philos. Trans. R. Soc. London, B
Volume:369
Issue / Number:1633
Start Page:1
End Page:9
Sequence Number of Article:20130149
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The idea that an NMDA receptor (NMDAR)−dependent long−term potentiation−like process in the hippocampus is the neural substrate for associative spatial learning and memory has proved to be extremely popular and influential. However, we recently reported that mice lacking NMDARs in dentate gyrus and CA1 hippocampal subfields (GluN1ΔDGCA1 mice) acquired the open field, spatial reference memory watermaze task as well as controls, a result that directly challenges this view. Here, we show that GluN1ΔDGCA1 mice were not impaired during acquisition of a spatial discrimination watermaze task, during which mice had to choose between two visually identical beacons, based on extramaze spatial cues, when all trials started at locations equidistant between the two beacons. They were subsequently impaired on test trials starting from close to the decoy beacon, conducted post−acquisition. GluN1ΔDGCA1 mice were also impaired during reversal of this spatial discrimination. Thus, contrary to the widely held belief, hippocampal NMDARs are not required for encoding associative, long−term spatial memories. Instead, hippocampal NMDARs, particularly in CA1, act as part of a comparator system to detect and resolve conflicts arising when two competing, behavioural response options are evoked concurrently, through activation of a behavioural inhibition system. These results have important implications for current theories of hippocampal function
Free Keywords:hippocampus, long−term potentiation, synaptic plasticity, spatial learning, watermaze, NMDAR
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:wkaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Max-Planck-Forschungsgruppe Neurophysiologie des Verhaltens (Andreas T. Schaefer)
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7943
URI:http%3A%2F%2Frstb.royalsocietypublishing.org%2Fcon...
URI:http%3A%2F%2Frstb.royalsocietypublishing.org%2Fcon...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24298...
DOI:10.1098%2Frstb.2013.0149
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