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          Institute: MPI für medizinische Forschung     Collection: Jahbruch 2014_archival     Display Documents



ID: 681440.0, MPI für medizinische Forschung / Jahbruch 2014_archival
Connectomic reconstruction of the inner plexiform layer in the mouse retina
Translation of Title:Connectomic reconstruction of the inner plexiform layer in the mouse retina
Authors:Helmstaedter, Moritz; Briggman, Kevin; Turaga, Srinivas C.; Jain, Viren; Seung, H. Sebastian; Denk, Winfried
Language:English
Date of Publication (YYYY-MM-DD):2013-08-08
Title of Journal:Nature
Journal Abbrev.:Nature
Volume:500
Issue / Number:7461
Start Page:168
End Page:174
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Comprehensive high−resolution structural maps are central to functional exploration and understanding in biology. For the nervous system, in which high resolution and large spatial extent are both needed, such maps are scarce as they challenge data acquisition and analysis capabilities. Here we present for the mouse inner plexiform layer−−the main computational neuropil region in the mammalian retina−−the dense reconstruction of 950 neurons and their mutual contacts. This was achieved by applying a combination of crowd−sourced manual annotation and machine−learning−based volume segmentation to serial block−face electron microscopy data. We characterize a new type of retinal bipolar interneuron and show that we can subdivide a known type based on connectivity. Circuit motifs that emerge from our data indicate a functional mechanism for a known cellular response in a ganglion cell that detects localized motion, and predict that another ganglion cell is motion sensitive
External Publication Status:published
Document Type:Article
Communicated by:wkaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Biomedizinische Optik
MPI für medizinische Forschung/Abteilung Zellphysiologie/Kortikale Schaltkreise
MPI für medizinische Forschung/Abteilung Biomedizinische Optik/Gruppe Moritz Helmstaedter
Identifiers:LOCALID:7938
URI:http%3A%2F%2Fwww.nature.com%2Fnature%2Fjournal%2Fv...
URI:http%3A%2F%2Fwww.nature.com%2Fnature%2Fjournal%2Fv...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23925...
DOI:10.1038%2Fnature12346
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