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          Institute: MPI für medizinische Forschung     Collection: Jahbruch 2014_archival     Display Documents



ID: 681444.0, MPI für medizinische Forschung / Jahbruch 2014_archival
Electroconvulsive therapy induces neurogenesis in frontal rat brain areas
Translation of Title:Electroconvulsive therapy induces neurogenesis in frontal rat brain areas
Authors:Inta, Dragos; Lima−Ojeda, Juan M.; Lau, Thorsten; Dormann, Christof; Tang, Wannan; Sprengel, Rolf; Schloss, Patrick; Sartorius, Alexander; Meyer−Lindenberg, Andreas; Gass, Peter
Language:English
Date of Publication (YYYY-MM-DD):2013-07-26
Title of Journal:PLoS ONE
Journal Abbrev.:PLoS ONE
Volume:8
Issue / Number:7
Start Page:1
End Page:5
Sequence Number of Article:69869
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Electroconvulsive therapy (ECT) is an effective therapy for several psychiatric disorders, including severe major depression, mania and certain forms of schizophrenia. It had been proposed that ECT acts by modulating local plasticity via the stimulation of neurogenesis. In fact, among antidepressant therapies, ECT is the most robust enhancer of neurogenesis in the hippocampus of rodents and non−human primates. The existence of ECT−triggered neurogenesis in other brain areas, particularly in those adjacent to the other main locus of neurogenesis, the subventricular zone (SVZ), had so far remained unknown. Here we show that ECT also strongly enhances neurogenesis in frontal brain areas, especially in the rostro−medial striatum, generating specific, small−size calretinin−positive interneurons. We provide here the first evidence that ECT stimulates neurogenesis in areas outside the hippocampus. Our data may open research possibilities that focus on the plastic changes induced by ECT in frontal limbic circuitry
External Publication Status:published
Document Type:Article
Communicated by:wkaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7927
URI:http%3A%2F%2Fwww.plosone.org%2Farticle%2FfetchObje...
URI:http%3A%2F%2Fwww.plosone.org%2Farticle%2Finfo%253A...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23922...
DOI:10.1371%2Fjournal.pone.0069869
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