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          Institute: MPI für medizinische Forschung     Collection: Jahbruch 2014_archival     Display Documents



ID: 681494.0, MPI für medizinische Forschung / Jahbruch 2014_archival
Controlled variations in stimulus similarity
during learning determine visual
discrimination capacity in freely moving
mice
Translation of Title:Controlled variations in stimulus similarity
during learning determine visual
discrimination capacity in freely moving
mice
Authors:Trevino, Mario; Oviedo, Tatiana; Jendritza, Patrick; Li, Shi−Bin; Köhr, Georg; De Marco, Rodrigo J
Language:English
Date of Publication (YYYY-MM-DD):2013-01-10
Title of Journal:Scientific Reports
Journal Abbrev.:Scientific Reports
Volume:3
Start Page:1
End Page:13
Sequence Number of Article:1048
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The mouse is receiving growing interest as a model organism for studying visual perception. However, little is known about how discrimination and learning interact to produce visual conditioned responses. Here, we adapted a two−alternative forced−choice visual discrimination task for mice.and examined how training with equiprobable stimuli of varying similarity influenced conditioned response and discrimination performance as a function of learning. Our results indicate that the slope of the gradients in similarity during training determined the learning rate, the maximum performance and the threshold for successful discrimination. Moreover, the learning process obeyed an inverse relationship between discrimination performance and discriminative resolution, implying that sensitivity within a similarity range cannot be improved without sacrificing performance in another. Our study demonstrates how the interplay between discrimination and learning controls visual discrimination capacity and introduces a new training protocol with quantitative measures to study perceptual learning and visually−guided behavior in freely moving mice
External Publication Status:published
Document Type:Article
Communicated by:wkaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Georg Köhr
Identifiers:LOCALID:7838
URI:http%3A%2F%2Fwww.nature.com%2Fsrep%2F2013%2F130110...
URI:http%3A%2F%2Fwww.nature.com%2Fsrep%2F2013%2F130110...
URI:http%3A%2F%2Fwww.nature.com%2Fsrep%2F2013%2F130110...
DOI:10.1038%2Fsrep01048
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