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          Institute: MPI für medizinische Forschung     Collection: Jahbruch 2014_archival     Display Documents



ID: 681495.0, MPI für medizinische Forschung / Jahbruch 2014_archival
Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior
Translation of Title:Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior
Authors:Ryan, Tomás J.; Kopanitsa, Maksym V.; Indersmitten, Tim; Nithianantharajah, Jess; Afinowi, Nurudeen O.; Pettit, Charles; Stanford, Lianne E.; Sprengel, Rolf; Saksida, Lisa M.; Bussey, Timothy J.; O'Dell, Thomas J.; Grant, Seth G. N.; Komiyama, Noboru H.
Language:English
Date of Publication (YYYY-MM-DD):2013-01-01
Title of Journal:Nature Neuroscience
Journal Abbrev.:Nat. Neurosci.
Volume:16
Issue / Number:1
Start Page:25
End Page:32
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Two genome duplications early in the vertebrate lineage expanded gene families, including GluN2 subunits of the NMDA receptor. Diversification between the four mammalian GluN2 proteins occurred primarily at their intracellular C−terminal domains (CTDs). To identify shared ancestral functions and diversified subunit−specific functions, we exchanged the exons encoding the GluN2A (also known as Grin2a) and GluN2B (also known as Grin2b) CTDs in two knock−in mice and analyzed the mice's biochemistry, synaptic physiology, and multiple learned and innate behaviors. The eight behaviors were genetically separated
into four groups, including one group comprising three types of learning linked to conserved GluN2A/B regions. In contrast,
the remaining five behaviors exhibited subunit−specific regulation. GluN2A/B CTD diversification conferred differential binding to cytoplasmic MAGUK proteins and differential forms of long−term potentiation. These data indicate that vertebrate behavior and synaptic signaling acquired increased complexity from the duplication and diversification of ancestral GluN2 genes
External Publication Status:published
Document Type:Article
Communicated by:wkaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Olfaction Web
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/Gruppe Rolf Sprengel
Identifiers:LOCALID:7836
URI:http%3A%2F%2Fwww.nature.com%2Fneuro%2Fjournal%2Fva...
URI:http%3A%2F%2Fwww.nature.com%2Fneuro%2Fjournal%2Fva...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23201...
DOI:10.1038%2Fnn.3277
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