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          Institute: MPI für medizinische Forschung     Collection: Jahbruch 2014_archival     Display Documents



ID: 681498.0, MPI für medizinische Forschung / Jahbruch 2014_archival
The neuromuscular junction: Selective remodeling of synaptic regulators at the nerve/muscle interface
Translation of Title:The neuromuscular junction: Selective remodeling of synaptic regulators at the nerve/muscle interface
Authors:Witzemann, Veit; Chevessier, Frédéric; Pacifici, Pier Giorgio; Yampolsky, Pessah
Language:English
Date of Publication (YYYY-MM-DD):2013-06-01
Title of Journal:Mechanisms of Development
Journal Abbrev.:Mechanisms of Development
Volume:130
Issue / Number:6
Start Page:402
End Page:411
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The peripheral synapses between motoneurons and skeletal muscle fibers, the neuromuscular junctions, are ideal to investigate the general principles of synaptogenesis that depend on the interaction of activity−dependent and activity−independent signals. Much has been learned from gene "knock out" mouse models that helped to identify major synaptic regulators. The "knock out" approach, however, may not distinguish between changes arising from the disruption of molecular signaling pathways and changes caused by the absence of synaptic transmission. To circumvent these problems, postsynaptic activity was modulated in mouse models by specifically targeting endplate receptors or the activity of synaptic regulators such as MuSK. Both regulators have multiple functions and acetylcholine receptors are not just signal transducers but regulate the localization and architecture of endplates. The results show that detailed analysis of mouse models will help to understand the complexity in mechanisms that regulate synaptic remodeling
Free Keywords:Neuromuscular junction;
Development;
Synapse formation;
Acetylcholine receptor;
Muscle specific kinase;
Mouse model;
Homologous recombination
External Publication Status:published
Document Type:Article
Communicated by:wkaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biophysik
MPI für medizinische Forschung/Abteilung Zellphysiologie
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie/Molekulare Anatomie neuromuskulärer Synapsen
MPI für medizinische Forschung/Arbeitsgruppe Witzemann / Koenen
Identifiers:LOCALID:7828
URI:http%3A%2F%2Fpdn.sciencedirect.com%2Fscience%3F_ob...
URI:http%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Fart...
URI:http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F23032...
DOI:10.1016%2Fj.mod.2012.09.004
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