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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 4 - Evolutionary Biology (R. Sommer)     Display Documents

ID: 681794.0, MPI für Entwicklungsbiologie / Abteilung 4 - Evolutionary Biology (R. Sommer)
A developmental switch coupled to the evolution of plasticity acts through a sulfatase
Authors:Ragsdale, E. J.; Mueller, M. R.; Roedelsperger, C.; Sommer, R. J.
Date of Publication (YYYY-MM-DD):2013-11-07
Title of Journal:Cell
Journal Abbrev.:Cell
Issue / Number:4
Start Page:922
End Page:933
Sequence Number of Article:24209628
Review Status:Internal review
Audience:Experts Only
Abstract / Description:Developmental plasticity has been suggested to facilitate phenotypic diversity, but the molecular mechanisms underlying this relationship are little understood. We analyzed a feeding dimorphism in Pristionchus nematodes whereby one of two alternative adult mouth forms is executed after an irreversible developmental decision. By integrating developmental genetics with functional tests in phenotypically divergent populations and species, we identified a regulator of plasticity, eud-1, that acts in a developmental switch. eud-1 mutations eliminate one mouth form, whereas overexpression of eud-1 fixes it. EUD-1 is a sulfatase that acts dosage dependently, is necessary and sufficient to control the sexual dimorphism of feeding forms, and has a conserved function in Pristionchus evolution. It is epistatic to known signaling cascades and results from lineage-specific gene duplications. EUD-1 thus executes a developmental switch for morphological plasticity in the adult stage, showing that regulatory pathways can evolve by terminal addition of new genes.
Free Keywords:Amino Acid Sequence; Animals; Base Sequence; Biological Evolution; Female; Gene Duplication; Gene Expression Regulation, Developmental; Male; Molecular Sequence Data; Mutation; Nematoda/classification/*enzymology/*genetics/growth & development; Phylogeny; Sex Characteristics; Sulfatases/*genetics
External Publication Status:published
Document Type:Article
Communicated by:MPI für Entwickungsbiologie
Affiliations:MPI für Entwicklungsbiologie/Abteilung 4 - Evolutionsbiologie (Ralf J. Sommer)
Identifiers:ISSN:1097-4172 (Electronic) 0092-8674 (Linking) %R 10.1... [ID No:1]
URL: [ID No:2]
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