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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 4 - Evolutionary Biology (R. Sommer)     Display Documents

ID: 681796.0, MPI für Entwicklungsbiologie / Abteilung 4 - Evolutionary Biology (R. Sommer)
Molecular evidence of 'Siisa form', a new genotype related to Onchocerca ochengi in cattle from North Cameroon
Authors:Eisenbarth, A.; Ekale, D.; Hildebrandt, J.; Achukwi, M. D.; Streit, A.; Renz, A.
Date of Publication (YYYY-MM-DD):2013-09
Title of Journal:Acta Tropica
Journal Abbrev.:Acta Tropica
Issue / Number:3
Start Page:261
End Page:265
Sequence Number of Article:23727461
Corporate Body:Elsevier
Review Status:Internal review
Audience:Experts Only
Abstract / Description:Onchocerca ochengi, a filarial nematode parasite from African Zebu cattle is considered to be the closest relative of Onchocerca volvulus, the causative agent of river blindness. Both Onchocerca species share the vector, black flies of the Simulium damnosum complex. Correct identification of their infective third-stage larvae in man-biting vectors is crucial to distinguish the transmission of human or animal parasites. In order to identify different closely related Onchocerca species we surveyed the sequences from the three mitochondrial loci 12S rRNA, 16S rRNA and coxI in both adult worms isolated from Onchocerca-induced nodules in cattle and infective third stage larvae isolated from vector flies from North Cameroon. Two distinct groups of mitochondrial haplotypes were found in cattle as well as in flies. One of them has been formerly mentioned in the literature as Onchocerca sp. 'Siisa', a filaria isolated from the vector S. damnosum sensu lato in Uganda with hitherto unknown host. Both variants are found sympatric, also in the same nodule of the animal host and in the vector. In the flies we also found the mitochondrial haplotype that had been described for O. volvulus which is about equally different from the two previously mentioned ones as they are from each other. These results suggest a higher genetic diversification of Onchocerca ochengi than previously reported. (C) 2013 Elsevier B.V. All rights reserved.
Free Keywords:onchocerca ochengi; onchocerca volvulus; siisa; bovine parasite; genotyping; volvulus infective larvae; sudan-savanna area; simulium-damnosum; filarial nematodes; bioclimatic zones; identification; transmission; DNA; phylogeny; parasite
External Publication Status:published
Document Type:Article
Communicated by:MPI für Entwickungsbiologie
Affiliations:MPI für Entwicklungsbiologie/Abteilung 4 - Evolutionsbiologie (Ralf J. Sommer)
External Affiliations:Univ Tubingen, Dept Comparat Zool, Inst Evolut & Ecol, Morgenstelle 28, D-72076 Tubingen, Germany Univ Tubingen, Dept Comparat Zool, Inst Evolut & Ecol, Morgenstelle 28, D-72076 Tubingen, Germany Univ Tubingen, Dept Comparat Zool, Inst Evolut & Ecol, D-72076 Tubingen, Germany Univ Tubingen, Programme Onchocercoses Field Stn, Ngaoundere, Cameroon Max Planck Inst Dev Biol, Dept Evolutionary Biol, D-72076 Tubingen, Germany Wakwa Reg Ctr, Inst Agr Res Dev, Vet Res Lab, Ngaoundere, Cameroon %G English
Identifiers:ISSN:0001-706X %R Doi 10.1016/J.Actatropica.2013.05.011 [ID No:1]
ISI:000322294800016 [ID No:2]
ISI:000322294800016 [ID No:3]
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