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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents

ID: 681890.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
Temperature-dependent regulation of flowering by antagonistic FLM variants
Authors:Pose, D.; Verhage, L.; Ott, F.; Yant, L.; Mathieu, J.; Angenent, G. C.; Immink, R. G.; Schmid, M.
Date of Publication (YYYY-MM-DD):2013-11-21
Title of Journal:Nature
Journal Abbrev.:Nature
Issue / Number:7476
Start Page:414
End Page:417
Sequence Number of Article:24067612
Review Status:Internal review
Audience:Experts Only
Abstract / Description:The appropriate timing of flowering is crucial for plant reproductive success. It is therefore not surprising that intricate genetic networks have evolved to perceive and integrate both endogenous and environmental signals, such as carbohydrate and hormonal status, photoperiod and temperature. In contrast to our detailed understanding of the vernalization pathway, little is known about how flowering time is controlled in response to changes in the ambient growth temperature. In Arabidopsis thaliana, the MADS-box transcription factor genes FLOWERING LOCUS M (FLM) and SHORT VEGETATIVE PHASE (SVP) have key roles in this process. FLM is subject to temperature-dependent alternative splicing. Here we report that the two main FLM protein splice variants, FLM-beta and FLM-delta, compete for interaction with the floral repressor SVP. The SVP-FLM-beta complex is predominately formed at low temperatures and prevents precocious flowering. By contrast, the competing SVP-FLM-delta complex is impaired in DNA binding and acts as a dominant-negative activator of flowering at higher temperatures. Our results show a new mechanism that controls the timing of the floral transition in response to changes in ambient temperature. A better understanding of how temperature controls the molecular mechanisms of flowering will be important to cope with current changes in global climate.
Free Keywords:Alternative Splicing/*genetics; Arabidopsis/genetics/*physiology; Arabidopsis Proteins/chemistry/genetics/*metabolism; DNA-Binding Proteins/chemistry/genetics/metabolism; Flowers/genetics/*physiology; Gene Expression Regulation, Plant; MADS Domain Proteins/chemistry/genetics/*metabolism; Plants, Genetically Modified; Protein Binding; Protein Isoforms/chemistry/genetics/*metabolism; *Temperature; Time Factors; Transcription Factors/metabolism
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
Identifiers:ISSN:1476-4687 (Electronic) 0028-0836 (Linking) %R 10.1... [ID No:1]
URL:http://www.ncbi.nlm.nih.gov/pubmed/24067612 [ID No:2]
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